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In March, the chief executive of Novavax said their vaccine might get authorized by the F.D.A. The Canadian company Entos Pharmaceuticals has created a DNA vaccine for the coronavirus. Out of 196 cases of Covid-19 among trial volunteers, 185 were in people who received the placebo. ImmunityBio launched a Phase 1 trial of a Covid-19 vaccine in October in the United States and another in South Africa in January. Updated Jan. 28, PRECLINICAL Vaccine name: INO-4800 APPROVED IN SWITZERLAND In March, BioNTech partnered with Pfizer to scale up the research, launching a clinical trial in May. Updated March 10, PHASE 3 Entos instead chose the gene for nucleocapsid, a protein that sits inside the virus’s membrane. Vaccine name: CoVLP Vaccines that contain viruses engineered to carry coronavirus genes. By December, the trial had reached its final total of 78 cases. Below is a list of all vaccines that have reached trials in humans, along with a selection of promising vaccines being tested in animals. How many have been vaccinated, and who’s eligible, Patients hospitalized and I.C.U. In July the U.S. government awarded Novavax another $1.6 billion to support the vaccine’s clinical trials and manufacturing.After getting promising results from preliminary studies in monkeys and humans, Novavax launched a Phase 2 trial on 2,900 people in South Africa in August, and the next month it launched a Phase 3 trial with up to 15,000 volunteers in the United Kingdom.A 30,000-person Phase 3 trial in the United States was delayed because of problems with manufacturing the doses required for the study. Dose: 2 doses, 4 weeks apart Updated Jan. 2, PHASE 1 In 2019, researchers at the University of Hong Kong and Xiamen University created a nasal-spray vaccine for the flu based on a genetically weakened form of the influenza virus. To make the intranasal vaccine, researchers outfitted a live attenuated vaccine against a different respiratory virus with the coronavirus spike protein. The Vaccine and Infectious Disease Organization at the University of Saskatchewan has developed a vaccine candidate which uses protein subunits to develop immunity against the coronavirus. On Dec. 29, Biological E and the Coalition for Epidemic Preparedness Innovations announced a partnership to advance the development and manufacturing of the vaccine, with CEPI initially contributing $5 million to the effort. Updated Feb. 18, PHASE 1 PHASE 2 COMBINED PHASES The vaccine, called ABCoV2, uses technology from consortium members AdaptVac and ExpreS2ion, among others. In addition, AstraZeneca later launched Phase 3 trials in Brazil, South Africa, and the United States.On Nov. 19, researchers published the first findings from the Phase 2/3 trials in the United Kingdom. Updated March 15, PHASE 1 But worry that the vaccine was rushed to approval led to widespread hesitancy. Updated Feb. 16, PHASE 1 Its stock price plunged 60 percent on the news. They hope the combination will enable the vaccine to produce immunity that’s both fast and long-lasting. In the live ticker, NDR.de will inform you today – on Wednesday, March 10, 2021 – about the consequences of the coronavirus pandemic for Lower Saxony, Schleswig-Holstein, Mecklenburg-Western Pomerania and Hamburg. On Oct. 17, a Phase 2/3 trial was launched in India.On Sept. 4, three weeks after Putin’s announcement, Gamaleya researchers published the results of their Phase 1/2 trial. Efficacy: Unknown In der ersten Woche soll es rund 20 Dosen pro Praxis geben, Ende April insgesamt mehr als für Impfzentren. On Feb. 25, China announced the approval of the CanSino vaccine for general use. The Bacillus Calmette-Guerin vaccine was developed in the early 1900s as a protection against tuberculosis. On Dec. 10, a vaccine from Australia’s University of Queensland was the first to be abandoned after entering a clinical trial. Pfizer and BioNTech found that the antibodies are somewhat less effective against another variant called B.1.351. The company expected to move to a Phase 3 trial in December and potentially seek emergency use authorization in the United States by spring. Cancelling the vaccine meant the collapse of a $1 billion deal with the Australian government for 51 million doses.The vaccine studies offered great promise at first. Breaking News. Approved for use in: Brazil NEW. Dose: 1 dose To further stimulate the immune system, the company is testing so-called adjuvants made by British drugmaker GSK and the American company Dynavax. Updated Feb. 2, PHASE 2 Type: Muscle injection The California-based company ImmunityBio created a vaccine using the Ad5 adenovirus, the same one used by CanSinBio and the Gamaleya Institute in Russia. The trial will determine whether the vaccine provides as much protection for them as for women who aren’t pregnant, and also gather information on its safety. To make the vaccine, researchers encode the RBD region in a gene, which they insert into a virus. Storage: Stable in refrigerator Die Resonanz ist enorm. That assumption turned out to be wrong. In recent years, they adapted it to create a vaccine for MERS, a disease caused by another coronavirus.This spring, they made an MVA-based vaccine for SARS-CoV-2, the coronavirus that is causing the Covid-19 pandemic. Vaccine experts decried the move as risky, and Russia later walked back the announcement, saying that the approval was a “conditional registration certificate,” which would depend on positive results from Phase 3 trials. Their candidate is composed of an adjuvant, along with a section of the spike protein called the receptor-binding domain. Vaccine name: Convidecia (also known as Ad5-nCoV) On Feb. 3, Vaxart announced that the trial revealed no serious safety concerns. It was cleared for human testing late last year by the Canadian government. Earlier this year, they engineered the vaccine to produce part of the coronavirus spike protein as well. The Murdoch Children’s Research Institute in Australia is conducting a Phase 3 trial called the BRACE to see if the vaccine partly protects against the coronavirus. In a Phase 1 trial, researchers are now testing the vaccine on 50 volunteers. It was also the first to be shown to be safe and effective with just one dose rather than two.The work that led to the vaccine started a decade ago at Beth Israel Deaconess Medical Center in Boston, where researchers developed a method for making vaccines out of a virus called Adenovirus 26, or Ad26 for short. Emergency use in: Mexico, Pakistan. PHASE 3 Singapore reached an agreement with Arcturus to spend up to $175 million to acquire vaccines when they’re ready. In addition to the spike protein, it also carries the gene for a protein called nucleocapsid. Vaccine name: Covaxin (also known as BBV152 A, B, C) After partnering with GSK, they launched a Phase 1/2 trial of the vaccine in February. PRECLINICAL TESTING: Scientists test a new vaccine on cells and then give it to animals such as mice or monkeys to see if it produces an immune response. South Korean vaccine producer EuBiologics launched a Phase 1/2 trial of a protein-based vaccine in late January. On Dec. 30, Sinopharm announced that the vaccine had an efficacy of 79.34 percent, leading the Chinese government to give it approval. The Beijing Institute of Biological Products created an inactivated coronavirus vaccine that was put into clinical trials by the state-owned Chinese company Sinopharm. The chief executive said in a March 4 interview that the vaccine could become available for children by September.The vaccine is being developed by Janssen Pharmaceutica, a Belgium-based division of Johnson & Johnson. Updated Feb. 8, PHASE 1 PHASE 2 COMBINED PHASES On Feb. 1, the center held a press conference to announce the start of a Phase 2 trial. On August 28, their Research Institute for Biological Safety Problems registered a Phase 1 trial on the vaccine, known as QazCovid. A special device uses a tiny electric pulse to deliver DNA through the skin. On Dec. 8, researchers with the University of Oxford and the British-Swedish company AstraZeneca published the first scientific paper on a Phase 3 clinical trial of a coronavirus vaccine. In February, they registered a placebo-controlled Phase 1/2 trial in Canada on 780 volunteers, comparing the effects from using one or two doses. In addition to their mRNA vaccine, Sanofi developed a Covid-19 vaccine based on viral proteins. Experiments on hamsters showed that the vaccine protected them from the coronavirus. Updated March. The Moderna vaccine is the second one authorized by the F.D.A., coming a week after the vaccine made by Pfizer and BioNTech.Like Pfizer and BioNTech, Moderna makes its vaccine from mRNA. Type: Muscle injection Form Title Purpose ; 79-SBG: NYS Motor Vehicle Inspection Regulations Amendment Small Business Regulation Guide : Small Business Regulation Guide that explains amendments made in 2008 to the NYS Motor Vehicle Inspection Regulations (Part 79). Updated Jan. 21, PHASE 2 mehr, In Niedersachsen soll der Einzelhandel in Modellkommunen ab Ende März wieder öffnen können. Working in collaboration with the Lazzaro Spallanzani National Institute for Infectious Diseases in Rome, they launched a Phase 1 trial at the end of July. The vaccine is based on a coronavirus protein which is produced in insect cells by genetically altered viruses. Updated Nov. 3, PHASE 1 Eine Woche geöffnete Kitas: Wie läuft der Regelbetrieb? Sinopharm said the vaccine’s efficacy was 72.51 percent. Dose: 2 doses, 3 weeks apart It contains a part of the spike protein, called RBD, along with two extra ingredients: proteins from a bacteria and aluminum hydroxide. They reported that the antibody response created by the vaccine was only modestly weaker against B.1.351. They launched a Phase 1 study of an RNA vaccine in late January. Storage: Stable in refrigerator for up to two years It’s currently the only Western company to be using this traditional method, which is also being pursued in China and India. Das neue Coronavirus Sars-CoV-2 hat sich weltweit ausgebreitet, auch die Menschen in Norddeutschland sind von Covid-19 betroffen. Last May, researchers published promising results from a Phase 1 safety trial on Convidecia, and in July they reported that their Phase 2 trials demonstrated the vaccine produced a strong immune response. They are exploring the possibility that such a vaccine could someday protect against a wide swath of coronaviruses, including ones that have yet to spill over from animal hosts. The results are expected in late 2021. put the vaccine on a partial hold due to questions about the delivery device. They registered a Phase 2/3 trial on March 10. Corona Extra®, Corona Light® and Corona … Approved for use in: China. mehr, Wie entwickelt sich die Zahl der Corona-Neuinfektionen? In Turkey, the efficacy against Covid-19 with at least one symptom was 83.5 percent. Notes and corrections: Early versions of the tracker combined two vaccines by Sinopharm into one entry, before subsequent reporting confirmed they were two different vaccines. If trials proceed as expected, researchers predict that at least one of their candidates will be ready by late 2021. There, the injected genes produce a natural signalling molecule called IL-12, which attracts the attention of immune cells that attack the cancer. Dose: 2 doses, 3 weeks apart The company hopes that this combination will provoke a strong immune response. The company also announced that it will begin testing the vaccine in babies and young children.For more details, see How Moderna’s Vaccine Works. Efficacy: 80.6% Known as EuCorVac-19, the vaccine combines the spike protein with an adjuvant that stimulates the immune system. In December they launched a Phase 1/2 trial with 345 participants. Mehr Corona-News im Live-Ticker. In special host cells, the molecules can give rise to full-blown viruses. In January the center announced that their initial formulation provided disappointing results and are postponing the trial until they update it. Earlier studies on monkeys reportedly showed protective effects, and in the Phase 1 trial indicated it was safe in people. On Feb. 25, the company announced it would advance to a Phase 2 trial in the second quarter of 2021. While it provided promising levels of antibodies in people under 50, older people did not respond as strongly as they had hoped. In February they added a Phase 2 trial to a U.S. registry, where they indicated the trial included 1,000 people and that the study would be completed by the end of the month. Der digitale Corona-Impfpass soll in drei Monaten kommen und europaweit gelten. On Nov. 2, the Canadian company Symvivo announced they had administered a DNA vaccine to their first volunteer in a Phase 1 trial. Coronavirus in Hamburg: Nachrichten und Hintergründe, "Alles hängt vom Tourismus ab" - Inseln fordern Konzept, Öffnung der Geschäfte: Fast alle wollen Modellregion werden, AstraZeneca: Kommunen wollen schnell wieder loslegen. On Feb. 16 the World Health Organization recommended the vaccine for emergency use in adults 18 or older. They also have an agreement with other countries, including the United Kingdom, Canada, Australia and South Korea. At the end of 2020, its creators applied to the F.D.A. The trial began in February. Vaccines typically require years of research and testing before reaching the clinic, but in 2020, scientists embarked on a race to produce safe and effective coronavirus vaccines in record time. The company is developing a new version of the vaccine that is tailored to emerging variants.In September, Novavax reached an agreement with the Serum Institute of India, a major vaccine manufacturer, that could enable them to produce as many as 2 billion doses a year. Researchers at the Institute of Medical Biology at the Chinese Academy of Medical Sciences, which has invented vaccines for polio and hepatitis A, created an inactivated coronavirus vaccine. By the end of the year, Russia planned on producing 20 million doses. On March 2, Merck announced it would assist Johnson & Johnson with manufacturing the vaccine.The European Union reached a similar deal on Oct. 8 for 200 million doses. Updated Jan. 14. The researchers registered a Phase 1 trial in Australia on Feb. 8. On Sept. 11 they registered a Phase 1 trial in Taiwan which led to 100 percent of volunteers producing antibodies without any serious side effects. On Feb. 19, Pfizer and BioNTech announced that they could keep the vaccine stable at -25°C to -15°C (-13°F to 5°F).In January, scientists grew concerned about the emergence of fast-spreading variants that might be able to evade antibodies. The commission claimed to have tested the vaccine on animals, but provided no data. EARLY USE IN RUSSIA Dose: 2 doses, 3 weeks apart They found that Sputnik V yielded antibodies to the coronavirus and mild side effects. In that study, they found that an adjuvant made by GSK produced promising levels of antibodies in volunteers. Updated Nov. 13, PHASE 1 NDV is a bird pathogen and does not cause symptoms in humans. Ratgeber für Eltern vom Bundesgesunheitsministeriums Updated Sept. 9, PHASE 1 Updated March 15, PHASE 3 In February the company registered a Phase 1 trial of an oral version of the vaccine. Type: Skin injection LIMITED USE IN U.A.E. On Dec. 22, the company announced a partnership with Pennsylvania-based Ocugen to develop Covaxin for the United States market.On Jan. 3, the Indian government granted Covaxin emergency authorization. 6.b Die Homepage der Nationalen Akademie der Wissenschaften Leopoldina D) Tipps, Tricks und Ratschläge. In September, Dr. Albert Bourla, the chief executive of Pfizer, said the Phase 3 trial would deliver enough results as soon as October to show if the vaccine worked or not. Updated Sept. 24, PHASE 1 PHASE 2 COMBINED PHASES Johnson & Johnson used Ad26 to develop vaccines for Ebola and other diseases with Ad26. The Phase 2 trial, which is recruiting up to 1,000 volunteers, started on Jan. 5. Vaccine name: ZyCoV-D Researchers registered a Phase 2 trial for the vaccine on Jan. 8. In October, the company began giving the pill to volunteers in a Phase 1 clinical trial. Corona-News-Ticker: Selbsttests an Schulen und ... - NDR.de The Abdala vaccine consists of a piece of the coronavirus spike protein called the receptor-binding domain. As the trials progressed, Pfizer and BioNTech also scaled up factories to produce Comirnaty in huge amounts. It’s hard to independently evaluate the claim from the isolated dictatorship. Moderna has made similar deals with other countries including Canada, Japan, Qatar and South Korea. Sources: World Health Organization, National Institute of Allergy and Infectious Diseases, National Center for Biotechnology Information, New England Journal of Medicine, Rollins School of Public Health at Emory University. In August, Arcturus launched a Phase 1/2 trial at Singapore General Hospital. The central Asian nation of Kazakhstan began research on a vaccine made from inactivated coronaviruses over the summer. Less than two months later, on Dec. 9, the U.A.E. Updated Dec. 29, PHASE 1 PHASE 2 COMBINED PHASES Dose: 2 doses, 3 weeks apart Other viral vector vaccines in active preclinical development include vaccines from: Ankara University; ID Pharma; Institut Pasteur Lille; KU Leuven; Ohio State University and Kazakh National Agrarian University; the Spanish National Center for Biotechnology and the Spanish National Research Council; TheraVectys and Institut Pasteur; Thomas Jefferson University and Bharat Biotech; Tonix Pharmaceuticals; University of Georgia; University of Helsinki, University of Eastern Finland, and Rokote Laboratories Finland; University of Pittsburgh; University of Western Ontario; Valo Therapeutics and University of Helsinki; Vivaldi Biosciences; Walvax Biotechnology, Tsinghua University, and Tianjin Medical University; Zydus Cadila. EARLY USE IN RUSSIA Approved for use in: China. Vaccine name: CVnCoV When an executive with the company was later asked about the difference between the U.A.E. Updated Dec. 12, PHASE 1 PHASE 2 COMBINED PHASES While it’s not clear how long this efficacy will last, Moderna has found that after three months the trial participants still have a strong immune defense against the coronavirus. In an unprecedented move in the coronavirus vaccine field, they announced on Dec. 11 that they would collaborate with the Russian creators of the Sputnik V vaccine, which is also made from adenoviruses, to see if a combination with Sputnik V might increase the efficacy of the Oxford-AstraZeneca vaccine. Bharat said that they would update their estimate of Covaxin’s efficacy up to 130 cases. Updated March 12, PHASE 1 PHASE 2 COMBINED PHASES On Nov. 5, Turkey’s Erciyes University announced they had begun injecting volunteers with an inactivated coronavirus vaccine called ERUCOV-VAC. On Jan. 3 the Indian government gave Zydus Cadila permission to advance to a Phase 3 trial with 30,000 volunteers. Type: Muscle injection April, Corona: Inzidenzwert in Papenburg kratzt an 400er-Marke, Impfgipfel bringt neuen Schwung in die Impfkampagne, Die Ergebnisse des Impfgipfels im Überblick, Nachtclub ÜberPop: Ein Jahr Corona-Krise in der Popkultur, Neustart der Impfungen mit AstraZeneca geglückt. Known as COVIran Barekat, it entered a Phase 1 trial at the end of December.