sodium polystyrene sulfonate

Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. The rectal enema form of this medicine is usually given by a healthcare professional. Avoid taking other medicines by mouth within 3 hours before or 3 hours after you take sodium polystyrene sulfonate (or 6 hours before/after if you have slow digestion). Copyright 1996-2021 Cerner Multum, Inc. The sodium polystyrene sulfonate enema is usually followed with a second cleansing enema. Sodium polystyrene sulfonate works differently from other medicines because it passes into your intestines without being absorbed into your blood stream. Call your doctor for medical advice about side effects. Commercially Available Suspension Shake the suspension well before administering. Tell your doctor about all your other medicines. 41688 Poly(styrene sulfonic acid) sodium salt, M.W. Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. If your dose is different, do not change it unless your doctor tells you to do so. Sorbitol may contribute to the risk of intestinal necrosis [see Warnings and Precautions (5.1)] and concomitant use is not recommended. This action occurs primarily in the large intestine, which excretes potassium ions to a greater degree than does the small intestine. Sodium polystyrene sulfonate is a cream to light brown, finely ground powder and is available in 453.6 g jars. Sodium polystyrene sulfonate, USP is a cream to light brown, finely ground powder and is available in 454 g jars and 15 g bottles. Limitation of Use: Sodium Polystyrene Sulfonate should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action [see Clinical Pharmacology (12.2)]. For non-prescription products, read the label or package ingredients carefully. Sodium polystyrene sulfonate works differently from other medicines because it passes into your intestines without being absorbed into your blood stream. One gram of Sodium Polystyrene Sulfonate contains 4.1 mEq of sodium. A client has a prescription to take sodium polystyrene sulfonate for several days. Written by Cerner Multum. The practical exchange ratio is 1 mEq K per 1 gram of resin. Premature infants or low birth weight infants may have an increased risk for gastrointestinal adverse effects with Sodium Polystyrene Sulfonate use [see Warnings and Precautions (5.4)]. Discontinue use in patients who develop constipation. Quasi-elastic light-scattering spectroscopy was used to measure the diffusion coefficient of polystyrene latex spheres of diameters 14, 67, and 189 nm in relatively dilute (concentrations 0 ≤ c ≤ 20 g/L) solutions of polystyrene sulfonate. Don't delay your care at Mayo Clinic. The intensity and duration of therapy depend upon the severity and resistance of hyperkalemia. Administer Sodium Polystyrene Sulfonate at least 3 hours before or 3 hours after other oral medications. Before Using The simultaneous oral administration of Sodium Polystyrene Sulfonate with nonabsorbable cation- donating antacids and laxatives may reduce the resin's potassium exchange capability and increase the risk of systemic alkalosis. Sodium Polystyrene Sulfonate is not totally selective for potassium, and small amounts of other cations such as magnesium and calcium can also be lost during treatment. SODIUM POLYSTYRENE SULFONATE (SOE dee um pol ee STYE reen SUHL fuh neyt) takes potassium out of the body by binding to it in the intestines. Sodium Polystyrene Sulfonate has the potential to bind other drugs. You may report side effects to FDA at 1-800-FDA-1088. [see Dosage and Administration (2.1) and Drug Interactions (7)]. To give this medicine orally: Mix the sodium polystyrene sulfonate powder with water, or with honey or jam to make it taste better. The client also needs to make some dietary changes. Decreased absorption of lithium and thyroxine have also been reported with co-administration of Sodium Polystyrene Sulfonate. The lowest GoodRx price for the most common version of generic Kayexalate is around $21.29, 38% off the average retail price of $34.84. Sodium Polystyrene Sulfonate is indicated for the treatment of hyperkalemia. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. pressure when sodium intake is not restricted, pre-sumably by promoting renal sodium retention. Sodium Polystyrene Sulfonate is not absorbed systemically following oral or rectal administration and maternal use is not expected to result in fetal risk. Patients with impaired gag reflex, altered level of consciousness, or patients prone to regurgitation may be at increased risk. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Sodium polystyrene sulfonate binds to many commonly prescribed oral medicines, decreasing the absorption and therefore the effectiveness of those oral medicines. Select one or more newsletters to continue. Administer with patient in an upright position [see Warnings and Precautions (5.4)]. Polymer molecular weights were in the range 1.5 ≤ M ≤ 1188 kDa; solvents were in the high-salt (0.2M NaCl) regime. Store at 25° C (77° F); excursions permitted to 15° – 30° C (59° – 86° F) [see USP Controlled Room Temperature]. This medicine may be used for other purposes; ask your health care provider or … Sodium Polystyrene Sulfonate may bind orally administered medications, which could decrease their gastrointestinal absorption and lead to reduced efficacy. SODIUM POLYSTYRENE SULFONATE takes potassium out of the body by binding to it in the intestines. Follow all directions on your prescription label and read all medication guides or instruction sheets. In both children and neonates, excessive dosage or inadequate dilution could result in impaction of the resin. Each 15 g dose of Sodium Polystyrene Sulfonate contains 1500 mg (60 mEq) of sodium. Monitor patients who are sensitive to sodium intake (heart failure, hypertension, edema) for signs of fluid overload. The in vivo efficiency of sodium-potassium exchange resins is approximately 33 percent; hence, about one third of the resin's actual sodium content is delivered to the body. Binding of Sodium Polystyrene Sulfonate to other oral medications could cause decreased gastrointestinal absorption and loss of efficacy when taken close to the time Sodium Polystyrene Sulfonate is administered. If you have a condition that slows your digestion, avoid taking other medicines by mouth within 6 hours before or 6 hours after you take sodium polystyrene sulfonate. The following information includes only the average doses of this medicine. Patients with gastroparesis may require a 6 hour separation. In vitro binding studies showed that Sodium Polystyrene Sulfonate bound significantly to the following tested drugs – warfarin, metoprolol, phenytoin, furosemide, amlodipine and amoxicillin. Uses; Before taking; Warnings; Dosage; Side effects; Storage; Uses of Sodium Polystyrene Sulfonate Powder: Stop using sodium polystyrene sulfonate and call your doctor at once if you have: severe constipation, severe stomach pain, bloating; confusion, thinking problems, feeling irritable; low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; low calcium levels--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes); or. Agitate the emulsion gently during administration. Sodium polystyrene sulfonate is used to treat hyperkalemia (increased amounts of potassium in the body). Which foods should the client avoid? Monitor calcium and magnesium in patients receiving Sodium Polystyrene Sulfonate. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Follow your doctor's orders or the directions on the label. Avoid use in patients who are at risk for developing constipation or impaction (including those with history of impaction, chronic constipation, inflammatory bowel disease, ischemic colitis, vascular intestinal atherosclerosis, previous bowel resection, or bowel obstruction). Sodium Polystyrene Sulfonate is a benzene, diethenyl-polymer, with ethenylbenzene, sulfonated, sodium salt and has the following structural formula: The drug is a cream to light brown finely ground, powdered form of Sodium Polystyrene Sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately 3.1 mEq (in vivo approximately 1 mEq) of potassium per gram. One level teaspoon contains approximately 3.5 g of Sodium Polystyrene Sulfonate and 15 mEq of sodium. The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an exchange capacity of approximately 3.1 mEq (approximately 1 mEq) of potassium per gram. Schedule your appointment now for safe in-person care. The enema will be inserted slowly while you are lying down. Applies to sodium polystyrene sulfonate: oral or rectal powder for suspension, oral or rectal suspension Side effects include: Gastric irritation, anorexia, constipation, diarrhea, fecal impaction, GI concretions (bezoars), nausea, vomiting, hypokalemia, hypocalcemia, hypomagnesemia, clinically important sodium retention. sodium polystyrene sulfonate) Administration of IV Insulin-Glucose, and inhaled beta-agonists (albuterol) IV Calcium administration to prevent cardiac arrythmias. This list is not complete. The amount of medicine that you take depends on the strength of the medicine. Oral. Generic Name: Sodium Polystyrene Sulfonate Powder (SOE dee um POL ee STYE reen SUL foe nate) Brand Name: Kayexalate, Kionex. exchange You may need to hold in the enema for up to several hours. Administer Sodium Polystyrene Sulfonate with the patient in an upright position. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. In in vitro binding studies, Sodium Polystyrene Sulfonate was shown to significantly bind the oral medications (n=6) that were tested. signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds. It is used to treat too much potassium in the body. Sodium Polystyrene Sulfonate is a potassium ion exchange resin composed of benzene -diethyl polymer with ethenyl-benzene, sulfonated, sodium salt. Drug Interactions. Dispense in tight, light-resistant containers as defined in the official compendia. Sodium polystyrene sulfonate is a cation-exchange resin taken orally that is used to reduce high levels of potassium in the blood (hyperkalemia). Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Risk factors for gastrointestinal adverse events were present in many of the cases including prematurity, history of intestinal disease or surgery, hypovolemia, and renal insufficiency and failure. Binding of potassium reduces the concentration of free potassium in the gastrointestinal lumen, resulting in a reduction of serum potassium levels. As the resin passes along the intestine or is retained in the colon after administration by enema, the sodium ions are partially released and are replaced by potassium ions. Sodium Polystyrene Sulfonate (By mouth) SOE-dee-um pol-ee-STYE-reen SUL-foe-nate. Patients with gastroparesis may require a 6 hour separation [see Warnings and Precautions (5.5) and Drug Interaction (7)]. Use the HNE Drug Lookup to find the prescription drugs that we consider medically appropriate and cost effective to keep health care affordable for everyone.. Is your drug covered? Do not use potassium supplements, calcium supplements, or salt substitutes while you are taking sodium polystyrene sulfonate, unless your doctor has told you to. Antacids or laxatives can make sodium polystyrene sulfonate less effective, or cause serious side effects. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Studies of safety and efficacy have not been conducted in pediatric patients. Ensure an adequate volume of cleansing solution (up to 2 liters) is utilized. Sodium Polystyrene Sulfonate is contraindicated in patients with the following conditions: Cases of intestinal necrosis, some fatal, and other serious gastrointestinal adverse events (bleeding, ischemic colitis, perforation) have been reported in association with Sodium Polystyrene Sulfonate use. The latest research on Global Sodium Polystyrene Sulfonate Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2025 comprises a fully comprehensive assessment of the industry vertical and highlights the various market segmentation. The sodium content is approximately 100 mg (4.1 mEq) per gram of the drug. Limitation of Use: Sodium Polystyrene Sulfonate should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action [see Clinical Pharmacology (12.2)]. Store at 25° C (77° F); excursions permitted to 15 to 30° C (59 to 86° F) [see USP Controlled Room Temperature], Distributed by Alexso, Inc. Los Angeles, CA 90064, sodium bicarbonate, Kayexalate, insulin regular, calcium gluconate, Humulin R, Veltassa. Tell your doctor if you are pregnant or breast-feeding. Sodium Polystyrene Sulfonate Suspension USP (SPS® Suspension) can be administered orally or in an enema. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Average adult dose: 15 g (approximately 4 level Teaspoons) one to four times daily in water. Hemodialysis or hemofiltration. Sodium Polystyrene Sulfonate increases fecal potassium excretion through binding of potassium in the lumen of the gastrointestinal tract. KAYEXALATE (sodium polystyrene sulfonate) is a cream or light brown fine powder of sodium polystyrene sulfonate. This medication is used to treat a high level of potassium in your blood. Cabbage Mushrooms Strawberries. Avoid use in patients who have not had a bowel movement post-surgery. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. See complete prescribing information. Some may affect sodium polystyrene sulfonate, especially: drugs that weaken the immune system such as cancer medicine, steroids, and medicines to prevent organ transplant rejection. Prepare suspension fresh and use within 24 hours. Suspend each dose in a small quantity of water or syrup, approximately 3 to 4 mL of liquid per gram of resin. Some drugs may have to be approved before the plan covers them. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Sodium Polystyrene Sulfonate is not absorbed systemically. Administer other oral medications at least 3 hours before or 3 hours after Sodium Polystyrene Sulfonate. The effective lowering of serum potassium with Sodium Polystyrene Sulfonate may take hours to days. Select all that apply. Polystyrene sulfonates are a group of medications used to treat high blood potassium. The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately 3.1 mEq (in vivo approximately 1 mEq) of potassium per gram.The sodium content is approximately 100 mg (4.1 mEq) per gram of the drug. Treats hyperkalemia (high levels of potassium in the blood). Avoid taking other medicines within 3 hours before or 3 hours after you take sodium polystyrene sulfonate. Do not heat Sodium Polystyrene Sulfonate as it could alter the exchange properties of the resin. After an initial cleansing enema, insert a soft, large size (French 28) rubber tube into the rectum for a distance of about 20 cm, with the tip well into the sigmoid colon, and tape in place. 16 Hypokalemia is rarely suspected on the basis of clinical presentation; the diagnosis is made by meas-urement of serum potassium. Administered as an oral suspension, sodium polystyrene sulfonate lowers serum potassium levels by exchanging its sodium ions for potassium ions. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or establish a causal relationship to drug exposure. Available for Android and iOS devices.
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