The HD-IIV4 replaces Fluzone High-Dose (trivalent). Background: Adults 65 years and older (seniors) experience more complications following influenza infection than younger adults. ... Age 65 and older to receive either Fluad or HD vaccine at 1:1 ratio. Fluzone high-dose (HD) is an inactivated influenza vaccine, formulated to contain four times the antigen content of the standard dose (SD) vaccine. FLUAD vs. FLUZONE HD Influenza Vaccine in Residents of Long Term Care. § RCT, double-blind ≥65 years: 6,107 HD-IIV3 3,051 SD-IIV3. Fluzone (IIV4) 0.5 mL (single-dose syringe) 0 6 months & older3 150 90686 0.5 mL (single-dose vial) 0 6 months & older3 150 90686 5.0 mL (multi-dose vial) 25 6 through 35 months3 158 90687 5.0 mL (multi-dose vial) 25 3 years & older 158 90688 Fluzone High-Dose (IIV4-HD) 0.7 mL (single-dose syringe) 0 65 … Blood will be sampled pre- and post-vaccine … HD … You can get both the high-dose and adjuvanted flu vaccines at your doctor's office, but you can also find the high dose … The high dose … Currently in the U.S., two influenza vaccines are licensed exclusively for use in seniors: an egg-grown trivalent inactivated high dose (HD-IIV3) influenza vaccine (Fluzone® High-Dose, Sanofi Pasteur) and an egg-grown trivalent inactivated adjuvanted (aIIV3) influenza vaccine (Fluad®, Seqirus). HD-IIV3 (Fluzone High-Dose, Sanofi Pasteur) SD-IIV3 (Fluzone)DiazGranadosCA et al, Vaccine 2013;31:861-66. Results from a clinical trial of more than 30,000 participants showed that adults 65 years and older who received the high dose vaccine had 24% fewer influenza illnesses as compared to those who received the standard dose flu vaccine. Fluzone High-Dose is indicated for active immunization of persons 65 years of age and older against influenza disease caused by influenza virus subtypes A and type B contained in the vaccine. Fluzone is specifically approved for the … We estimated the relative vaccine effectiveness (rVE) of a trivalent high dose (HD … 2009-10 (H1N1pdm09; not contained in HD … The high-dose vaccines, however, contain four times as much flu virus antigen — the part of the vaccine that stimulates the immune system — as regular Fluzone … There are two types of vaccines that the CDC recommends for people over 65: the high dose flu vaccine, also called Fluzone, and the adjuvanted flu vaccine, known as Fluad. ACIP’s flu vaccine recommnedations for 2020-21 were updated to outline the composition of this year’s vaccines, as well as two newly licensed influenza vaccines—Fluzone High-Dose Quadrivalent and Fluad Quadrivalent—for patients ≥65 … A new vaccine called Fluzone High-Dose Quadrivalent that is made up of four flu strains has been approved for people age 65 and older. Fluzone High-Dose Quadrivalent (HD-IIV4, Sanofi Pasteur) and Fluad Quadrivalent (Seqirus), both for adults 65 years and older, are new for 2020–21.
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